Principles of Inheritance and Variation Question 185
185. Sickle cell anaemia is induced by
[2001]
(a) change of amino acid in a-chain of haemoglobin
(b) change of amino acid in b-chain of haemoglobin
(c) change of amino acid in both a- and b-chain of haemoglobin
(d) change of amino acid in either a- or b-chain of haemoglobin
Show Answer
Answer : b
Hints & Solution
(b) Sickle cell anaemia is a hereditary disorder of autosomal nature caused by mutation of the gene controlling b-chain of haemoglobin. It involves substitution of glutamine by valine.
