Principles of Inheritance and Variation Question 185

185. Sickle cell anaemia is induced by

[2001]

(a) change of amino acid in a-chain of haemoglobin

(b) change of amino acid in b-chain of haemoglobin

(c) change of amino acid in both a- and b-chain of haemoglobin

(d) change of amino acid in either a- or b-chain of haemoglobin

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Answer : b

Hints & Solution

(b) Sickle cell anaemia is a hereditary disorder of autosomal nature caused by mutation of the gene controlling b-chain of haemoglobin. It involves substitution of glutamine by valine.