Chemical and Ionic Equilibrium 2 Question 25

25. The pKa of acetyl salicylic acid (aspirin) is 3.5 . The pH of gastric juice in human stomach is about 2-3 and the pH in the small intestine is about 8 . Aspirin will be

(1988,1M)

(a) unionised in the small intestine and in the stomach

(b) completely ionised in the small intestine and in the stomach

(c) ionised in the stomach and almost unionised in the small intestine

(d) ionised in the small intestine and almost unionised in the stomach

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Solution:

  1. In stomach, pH is 23, i.e. strongly acidic and aspirin will be almost unionised here due to common ion effect. However, pH in small intestine is 8 , basic, aspirin will be neutralised here.