Principles of Inheritance and Variation Question 159
159. The genetic defect - Adenosine deaminase (ADA) deficiency may be cured permanently by:
[2009]
(a) administering adenosine deaminase activators.
(b) introducing bone marrow cells producing $ADA$ into cells at early embryonic stages.
(c) enzyme replacement therapy.
(d) periodic infusion of genetically engineered lymphocytes having functional ADA cDNA.
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Answer : b
Hints & Solution
(b) By introducing bone marrow cells producing $ADA$ into cells at early embryonic stages, the genetic defect adenosine deaminase (ADA) deficiency may be cured permanently. It is due to mutation.
