Unit 16 Chemistry In Everyday Life-Delelted
By now, you have learnt the basic principles of chemistry and also realised that it influences every sphere of human life. The principles of chemistry have been used for the benefit of mankind. Think of cleanliness - the materials like soaps, detergents, household bleaches, tooth pastes, etc. will come to your mind. Look towards the beautiful clothes - immediately chemicals of the synthetic fibres used for making clothes and chemicals giving colours to them will come to your mind. Food materials - again a number of chemicals about which you have learnt in the previous Unit will appear in your mind. Of course, sickness and diseases remind us of medicines - again chemicals. Explosives, fuels, rocket propellents, building and electronic materials, etc., are all chemicals. Chemistry has influenced our life so much that we do not even realise that we come across chemicals at every moment; that we ourselves are beautiful chemical creations and all our activities are controlled by chemicals. In this Unit, we shall learn the application of Chemistry in three important and interesting areas, namely - medicines, food materials and cleansing agents.
16.1 Drugs and their Classification
Drugs are chemicals of low molecular masses ( 100 - 500u). These interact with macromolecular targets and produce a biological response. When the biological response is therapeutic and useful, these chemicals are called medicines and are used in diagnosis, prevention and treatment of diseases. If taken in doses higher than those recommended, most of the drugs used as medicines are potential poisons. Use of chemicals for therapeutic effect is called chemotherapy,
16.1.1 Classification of Drugs
Drugs can be classified mainly on criteria outlined as follows:
(a) On the basis of pharmacological effect
This classification is based on pharmacological effect of the drugs. It is useful for doctors because it provides them the whole range of drugs available for the treatment of a particular type of problem. For example, analgesics have pain killing effect, antiseptics kill or arrest the growth of microorganisms.
(b) On the basis of drug action
It is based on the action of a drug on a particular biochemical process. For example, all antihistamines inhibit the action of the compound, histamine which causes inflammation in the body. There are various ways in which action of histamines can be blocked. You will learn about this in Section 16.3.2.
(c) On the basis of chemical structure
It is based on the chemical structure of the drug. Drugs classified in this way share common structural features and often have similar pharmacological activity. For example, sulphonamides have common structural feature, given below.
(d) On the basis of molecular targets
Drugs usually interact with biomolecules such as carbohydrates, lipids, proteins and nucleic acids. These are called target molecules or drug targets. Drugs possessing some common structural features may have the same mechanism of action on targets. The classification based on molecular targets is the most useful classification for medicinal chemists.
16.2 Drug-Target Interaction
Macromolecules of biological origin perform various functions in the body. For example, proteins which perform the role of biological catalysts in the body are called enzymes, those which are crucial to communication system in the body are called receptors. Carrier proteins carry polar molecules across the cell membrane. Nucleic acids have coded genetic information for the cell. Lipids and carbohydrates are structural parts of the cell membrane. We shall explain the drug-target interaction with the examples of enzymes and receptors.
16.2.1 Enzymes as Drug Targets
(a) Catalytic action of enzymes
For understanding the interaction between a drug and an enzyme, it is important to know how do enzymes catalyse the reaction (Section 5.2.4). In their catalytic activity, enzymes perform two major functions:
(i) The first function of an enzyme is to hold the substrate for a chemical reaction. Active sites of enzymes hold the substrate molecule in a suitable position, so that it can be attacked by the reagent effectively.
Substrates bind to the active site of the enzyme through a variety of interactions such as ionic bonding, hydrogen bonding, van der Waals interaction or dipole-dipole interaction (Fig. 16.1).
(ii) The second function of an enzyme is to provide functional groups that will attack the substrate and carry out chemical reaction.
(b) Drug-enzyme interaction
Drugs inhibit any of the above mentioned activities of enzymes. These can block the binding site of the enzyme and prevent the binding of substrate, or can inhibit the catalytic activity of the enzyme. Such drugs are called enzyme inhibitors.
Drugs inhibit the attachment of substrate on active site of enzymes in two different ways;
(i) Drugs compete with the natural substrate for their attachment on the active sites of enzymes. Such drugs are called competitive inhibitors (Fig. 16.2).
(ii) Some drugs do not bind to the enzyme’s active site. These bind to a different site of enzyme which is called allosteric site. This binding of inhibitor at allosteric site (Fig.16.3) changes the shape of the active site in such a way that substrate cannot recognise it.
If the bond formed between an enzyme and an inhibitor is a strong covalent bond and cannot be broken easily, then the enzyme is blocked permanently. The body then degrades the enzyme-inhibitor complex and synthesises the new enzyme.
16.2.2 Receptors as Drug Targets
Receptors are proteins that are crucial to body’s communication process. Majority of these are embedded in cell membranes (Fig. 16.4). Receptor proteins are embedded in the cell membrane in such a way that their small part possessing active site projects out of the surface of the membrane and opens on the outside region of the cell membrane (Fig. 16.4).
In the body, message between two neurons and that between neurons to muscles is communicated through certain chemicals. These chemicals, known as chemical messengers are received at the binding sites of receptor proteins. To accommodate a messenger, shape of the receptor site changes. This brings about the transfer of message into the cell. Thus, chemical messenger gives message to the cell without entering the cell (Fig. 16.5).
There are a large number of different receptors in the body that interact with different chemical messengers. These receptors show selectivity for one chemical messenger over the other because their binding sites have different shape, structure and amino acid composition.
Drugs that bind to the receptor site and inhibit its natural function are called antagonists. These are useful when blocking of message is required. There are other types of drugs that mimic the natural messenger by switching on the receptor, these are called agonists. These are useful when there is lack of natural chemical messenger.
16.3 Therapeutic Action of Different Classes of Drugs
In this Section, we shall discuss the therapeutic action of a few important classes of drugs.
16.3.1 Antacids
Over production of acid in the stomach causes irritation and pain. In severe cases, ulcers are developed in the stomach. Until 1970, only treatment for acidity was administration of antacids, such as sodium hydrogencarbonate or a mixture of aluminium and magnesium hydroxide. However, excessive hydrogencarbonate can make the stomach alkaline and trigger the production of even more acid. Metal hydroxides are better alternatives because of being insoluble, these do not increase the pH above neutrality. These treatments control only symptoms, and not the cause. Therefore, with these metal salts, the patients cannot be treated easily. In advanced stages, ulcers become life threatening and its only treatment is removal of the affected part of the stomach.
A major breakthrough in the treatment of hyperacidity came through the discovery according to which a chemical, histamine, stimulates the secretion of pepsin and hydrochloric acid in the stomach. The drug cimetidine (Tegamet), was designed to prevent the interaction of histamine with the receptors present in the stomach wall. This resulted in release of lesser amount of acid. The importance of the drug was so much that it remained the largest selling drug in the world until another drug, ranitidine (Zantac), was discovered.
16.3.2 Antihistamines
Histamine is a potent vasodilator. It has various functions. It contracts the smooth muscles in the bronchi and gut and relaxes other muscles, such as those in the walls of fine blood vessels. Histamine is also responsible for the nasal congestion associated with common cold and allergic response to pollen.
Synthetic drugs, brompheniramine (Dimetapp) and terfenadine (Seldane), act as antihistamines. They interfere with the natural action of histamine by competing with histamine for binding sites of receptor where histamine exerts its effect.
Now the question that arises is, “Why do above mentioned antihistamines not affect the secretion of acid in stomach?” The reason is that antiallergic and antacid drugs work on different receptors.
16.3.3 Neurologically Active Drugs
(a) Tranquilizers
Tranquilizers and analgesics are neurologically active drugs. These affect the message transfer mechanism from nerve to receptor. Tranquilizers are a class of chemical compounds used for the treatment of stress, and mild or even severe mental diseases. These relieve anxiety, stress, irritability or excitement by inducing a sense of well-being. They form an essential component of sleeping pills. There are various types of tranquilizers. They function by different mechanisms. For example, noradrenaline is one of the neurotransmitters that plays a role in mood changes. If the level of noradrenaline is low for some reason, then the signal-sending activity becomes low, and the person suffers from depression. In such situations, antidepressant drugs are required. These drugs inhibit the enzymes which catalyse the degradation of noradrenaline. If the enzyme is inhibited, this important neurotransmitter is slowly metabolised and can activate its receptor for longer periods of time, thus counteracting the effect of depression. Iproniazid and phenelzine are two such drugs.
Some tranquilizers namely, chlordiazepoxide and meprobamate, are relatively mild tranquilizers suitable for relieving tension. Equanil is used in controlling depression and hypertension.
Derivatives of barbituric acid viz., veronal, amytal, nembutal, luminal and seconal constitute an important class of tranquilizers. These derivatives are called barbiturates. Barbiturates are hypnotic, i.e., sleep producing agents. Some other substances used as tranquilizers are valium and serotonin.
(b) Analgesics
Analgesics reduce or abolish pain without causing impairment of consciousness, mental confusion, incoordination or paralysis or some other disturbances of nervous system. These are classified as follows: (i) Non-narcotic (non-addictive) analgesics (ii) Narcotic drugs
(i) Non-narcotic (non-addictive) analgesics: Aspirin and paracetamol belong to the class of non-narcotic analgesics. Aspirin is the most familiar example. Aspirin inhibits the synthesis of chemicals known as prostaglandins which stimulate inflammation in the tissue and cause pain. These drugs are effective in relieving skeletal pain such as that due to arthritis. These drugs have many other effects such as reducing fever (antipyretic) and preventing platelet coagulation. Because of its anti blood clotting action, aspirin finds use in prevention of heart attacks.
(ii) Narcotic analgesics: Morphine and many of its homologues, when administered in medicinal doses, relieve pain and produce sleep. In poisonous doses, these produce stupor, coma, convulsions and ultimately death. Morphine narcotics are sometimes referred to as opiates, since they are obtained from the opium poppy.
These analgesics are chiefly used for the relief of postoperative pain, cardiac pain and pains of terminal cancer, and in child birth.
16.3.4 Antimicrobials
Diseases in human beings and animals may be caused by a variety of microorganisms such as bacteria, virus, fungi and other pathogens. An antimicrobial tends to destroy/prevent development or inhibit the pathogenic action of microbes such as bacteria (antibacterial drugs), fungi (antifungal agents), virus (antiviral agents), or other parasites (antiparasitic drugs) selectively. Antibiotics, antiseptics and disinfectants are antimicrobial drugs.
(a) Antibiotics
Antibiotics are used as drugs to treat infections because of their low toxicity for humans and animals. Initially antibiotics were classified as chemical substances produced by microorganisms (bacteria, fungi and molds) that inhibit the growth or even destroy microorganisms. The development of synthetic methods has helped in synthesising some of the compounds that were originally discovered as products of microorganisms. Also, some purely synthetic compounds have antibacterial activity, and therefore, definition of antibiotic has been modified. An antibiotic now refers to a substance produced wholly or partly by chemical synthesis, which in low concentrations inhibits the growth or destroys microorganisms by intervening in their metabolic processes.
The search for chemicals that would adversely affect invading bacteria but not the host began in the nineteenth century. Paul Ehrlich, a German bacteriologist, conceived this idea. He investigated arsenic based structures in order to produce less toxic substances for the treatment of syphilis. He developed the medicine, arsphenamine, known as salvarsan. Paul Ehrlich got Nobel prize for Medicine in 1908 for this discovery. It was the first effective treatment discovered for syphilis. Although salvarsan is toxic to human beings, its effect on the bacteria, spirochete, which causes syphilis is much greater than on human beings. At the same time, Ehrlich was working on azodyes also. He noted that there is similarity in structures of salvarsan and
azodyes. The –As = As– linkage present in arsphenamine resembles the –N = N - linkage present in azodyes in the sense that arsenic atom is present in place of nitrogen. He also noted tissues getting coloured by dyes selectively. Therefore, Ehrlich began to search for the compounds which resemble in structure to azodyes and selectively bind to bacteria. In 1932, he succeeded in preparing the first effective antibacterial agent, prontosil, which resembles in structure to the compound, salvarsan. Soon it was discovered that in the body prontosil is converted to a compound called sulphanilamide, which is the real active compound. Thus the sulpha drugs were discovered. A large range of sulphonamide analogues was synthesised. One of the most effective is sulphapyridine.
Despite the success of sulfonamides, the real revolution in antibacterial therapy began with the discovery of Alexander Fleming in 1929, of the antibacterial properties of a Penicillium fungus. Isolation and purification of active compound to accumulate sufficient material for clinical trials took thirteen years.
Antibiotics have either cidal (killing) effect or a static (inhibitory) effect on microbes. A few examples of the two types of antibiotics are as follows:
$$ \begin{array}{ll} \text{Bactericidal } & \text{ Bacteriostatic} \\ \text{Penicillin } & \text{Erythromycin } \\ \text{Aminoglycosides} & \text{Tetracycline } \\ \text{Ofloxacin} & \text{ Chloramphenicol } \\ \end{array} $$
The range of bacteria or other microorganisms that are affected by a certain antibiotic is expressed as its spectrum of action. Antibiotics which kill or inhibit a wide range of Gram-positive and Gram-negative bacteria are said to be broad spectrum antibiotics. Those effective mainly against Gram-positive or Gram-negative bacteria are narrow spectrum antibiotics. If effective against a single organism or disease, they are referred to as limited spectrum antibiotics. Penicillin G has a narrow spectrum. Ampicillin and Amoxycillin are synthetic modifications of penicillins. These have broad spectrum. It is absolutely essential to test the patients for sensitivity (allergy) to penicillin before it is administered. In India, penicillin is manufactured at the Hindustan Antibiotics in Pimpri and in private sector industry.
Chloramphenicol, isolated in 1947, is a broad spectrum antibiotic. It is rapidly absorbed from the gastrointestinal tract and hence can be given orally in case of typhoid, dysentery, acute fever, certain form of urinary infections, meningitis and pneumonia. Vancomycin and ofloxacin are the other important broad spectrum antibiotics. The antibiotic dysidazirine is supposed to be toxic towards certain strains of cancer cells.
(b) Antiseptics and disinfectants
Antiseptics and disinfectants are also the chemicals which either kill or prevent the growth of microorganisms.
Antiseptics are applied to the living tissues such as wounds, cuts, ulcers and diseased skin surfaces. Examples are furacine, soframicine, etc. These are not ingested like antibiotics. Commonly used antiseptic, dettol is a mixture of chloroxylenol and terpineol. Bithionol (the compound is also called bithional) is added to soaps to impart antiseptic properties. Iodine is a powerful antiseptic. Its 2-3 per cent solution in alcoholwater mixture is known as tincture of iodine. It is applied on wounds. Iodoform is also used as an antiseptic for wounds. Boric acid in dilute aqueous solution is weak antiseptic for eyes.
Disinfectants are applied to inanimate objects such as floors, drainage system, instruments, etc. Same substances can act as an antiseptic as well as disinfectant by varying the concentration. For example, 0.2 per cent solution of phenol is an antiseptic while its one percent solution is disinfectant.
Chlorine in the concentration of 0.2 to 0.4 ppm in aqueous solution and sulphur dioxide in very low concentrations, are disinfectants.
16.3.5 Antifertility Drugs
Antibiotic revolution has provided long and healthy life to people. The life expectancy has almost doubled. The increased population has caused many social problems in terms of food resources, environmental issues, employment, etc. To control these problems, population is required to be controlled. This has lead to the concept of family planning. Antifertility drugs are of use in this direction. Birth control pills essentially contain a mixture of synthetic estrogen and progesterone derivatives. Both of these compounds are hormones. It is known that progesterone suppresses ovulation. Synthetic progesterone derivatives are more potent than progesterone. Norethindrone is an example of synthetic progesterone derivative most widely used as antifertility drug. The estrogen derivative which is used in combination with progesterone derivative is ethynylestradiol (novestrol).
Intext Questions
16.1 Sleeping pills are recommended by doctors to the patients suffering from sleeplessness but it is not advisable to take its doses without consultation with the doctor. Why?
Answer Most drugs when taken in doses higher than recommended may cause harmful effects and sometimes, may even lead to death. Hence, a doctor should always be consulted before taking any medicine.Show Answer
Show Answer
Answer
The given statement refers to the classification of pharmacological effects of the drug. This is because any drug that is used to counteract the effects of excess acid in the stomach is called an antacid
16.4 Chemicals in Food
Chemicals are added to food for (i) their preservation, (ii) enhancing their appeal, and (iii) adding nutritive value in them. Main categories of food additives are as follows:
(i) Food colours
(ii) Flavours and sweeteners
(iii) Fat emulsifiers and stabilising agents
(iv) Flour improvers - antistaling agents and bleaches
(v) Antioxidants
(vi) Preservatives
(vii) Nutritional supplements such as minerals, vitamins and amino acids.
Except for chemicals of category (vii), none of the above additives have nutritive value. These are added either to increase the shelf life of stored food or for cosmetic purposes. In this Section we will discuss only sweeteners and food preservatives.
16.4.1 Artificial Sweetening Agents
Natural sweeteners, e.g., sucrose add to calorie intake and therefore many people prefer to use artificial sweeteners. Ortho-sulphobenzimide, also called saccharin, is the first popular artificial sweetening agent. It has been used as a sweetening agent ever since it was discovered in 1879. It is about 550 times as sweet as cane sugar. It is excreted from the body in urine unchanged. It appears to be entirely inert and harmless when taken. Its use is of great value to diabetic persons and people who need to control intake of calories. Some other commonly marketed artificial sweeteners are given in Table 16.1
Aspartame is the most successful and widely used artificial sweetener. It is roughly 100 times as sweet as cane sugar. It is methyl ester of dipeptide formed from aspartic acid and phenylalanine. Use of aspartame is limited to cold foods and soft drinks because it is unstable at cooking temperature.
Alitame is high potency sweetener, although it is more stable than aspartame, the control of sweetness of food is difficult while using it.
Sucralose is trichloro derivative of sucrose. Its appearance and taste are like sugar. It is stable at cooking temperature. It does not provide calories.
16.4.2 Food Preservatives
Food preservatives prevent spoilage of food due to prohibiting microbial growth. The most commonly used preservatives include table salt, sugar, vegetable oils and sodium benzoate, C6H5COONa. Sodium benzoate is used in limited quantities and is metabolised in the body. Salts of sorbic acid and propanoic acid are also used as preservatives.
Intex Question
16.3 Why do we require artificial sweetening agents?
Answer
A large number of people are suffering from diseases such as diabetes and obesity. These people cannot take normal sugar i.e., sucrose as it is harmful for them. Therefore, artificial sweetening agents that do not add to the calorie intake of a person are required. Saccharin, aspartame, and alitame are a few examples of artificial sweeteners.
16.5 Cleansing Agents
In this Section, we will learn about detergents. Two types of detergents are used as cleansing agents. These are soaps and synthetic detergents. These improve cleansing properties of water. These help in removal of fats which bind other materials to the fabric or skin.
16.5.1 Soaps
Soaps are the detergents used since long. Soaps used for cleaning purpose are sodium or potassium salts of long chain fatty acids, e.g., stearic, oleic and palmitic acids. Soaps containing sodium salts are formed by heating fat (i.e., glyceryl ester of fatty acid) with aqueous sodium hydroxide solution. This reaction is known as saponification.
In this reaction, esters of fatty acids are hydrolysed and the soap obtained remains in colloidal form. It is precipitated from the solution by adding sodium chloride. The solution left after removing the soap contains glycerol, which can be recovered by fractional distillation. Only sodium and potassium soaps are soluble in water and are used for cleaning purposes. Generally potassium soaps are soft to the skin than sodium soaps. These can be prepared by using potassium hydroxide solution in place of sodium hydroxide.
Types of soaps
Basically all soaps are made by boiling fats or oils with suitable soluble hydroxide. Variations are made by using different raw materials.
Toilet soaps are prepared by using better grades of fats and oils and care is taken to remove excess alkali. Colour and perfumes are added to make these more attractive.
Soaps that float in water are made by beating tiny air bubbles before their hardening. Transparent soaps are made by dissolving the soap in ethanol and then evaporating the excess solvent.
In medicated soaps, substances of medicinal value are added. In some soaps, deodorants are added. Shaving soaps contain glycerol to prevent rapid drying. A gum called, rosin is added while making them. It forms sodium rosinate which lathers well. Laundry soaps contain fillers like sodium rosinate, sodium silicate, borax and sodium carbonate.
Soap chips are made by running a thin sheet of melted soap onto a cool cylinder and scraping off the soaps in small broken pieces. Soap granules are dried miniature soap bubbles. Soap powders and scouring soaps contain some soap, a scouring agent (abrasive) such as powdered pumice or finely divided sand, and builders like sodium carbonate and trisodium phosphate. Builders make the soaps act more rapidly. The cleansing action of soap has been discussed in Unit 5.
Why do soaps not work in hard water?
Hard water contains calcium and magnesium ions. These ions form insoluble calcium and magnesium soaps respectively when sodium or potassium soaps are dissolved in hard water.
$$ \underset{\text{Soap}}{\mathrm{2C_{17}H_{35}COONa}} + \mathrm{CaCl_2} \longrightarrow \mathrm{2NaCl} + \underset{\substack{\text{Insoluble calcium} \\ \text{stearate(Soap)}}}{\mathrm{(C_{17}H_{35}COO)_2Ca}} $$
These insoluble soaps separate as scum in water and are useless as cleansing agent. In fact these are hinderance to good washing, because the precipitate adheres onto the fibre of the cloth as gummy mass. Hair washed with hard water looks dull because of this sticky precipitate. Dye does not absorb evenly on cloth washed with soap using hard water, because of this gummy mass.
16.5.2 Synthetic Detergents
Synthetic detergents are cleansing agents which have all the properties of soaps, but which actually do not contain any soap. These can be used both in soft and hard water as they give foam even in hard water. Some of the detergents give foam even in ice cold water.
Synthetic detergents are mainly classified into three categories: (i) Anionic detergents (ii) Cationic detergents and (iii) Non-ionic detergents
(i) Anionic Detergents: Anionic detergents are sodium salts of sulphonated long chain alcohols or hydrocarbons. Alkyl hydrogensulphates formed by treating long chain alcohols with concentrated sulphuric acid are neutralised with alkali to form anionic detergents. Similarly alkyl benzene sulphonates are obtained by neutralising alkyl benzene sulphonic acids with alkali.
In anionic detergents, the anionic part of the molecule is involved in the cleansing action. Sodium salts of alkylbenzenesulphonates are an important class of anionic detergents.
They are mostly used for household work. Anionic detergents are also used in toothpastes.
(ii) Cationic Detergents: Cationic detergents are quarternary ammonium salts of amines with acetates, chlorides or bromides as anions. Cationic part possess a long hydrocarbon chain and a positive charge on nitrogen atom. Hence, these are called cationic detergents. Cetyltrimethylammonium bromide is a popular cationic detergent and is used in hair conditioners.
Cationic detergents have germicidal properties and are expensive, therefore, these are of limited use.
(iii) Non-ionic Detergents: Non-ionic detergents do not contain any ion in their constitution. One such detergent is formed when stearic acid reacts with polyethyleneglycol.
$ \underset{\text{Stearic acid}}{\mathrm{CH_3(CH_2)_{16}COOH}} + \underset{\text{Polyethyleneglycol}}{\mathrm{HO(CH_2CH_2O)_nCH_2CH_2OH}} \xrightarrow{-\mathrm{H_2O}} $
$\mathrm{CH_3} \mathrm{(CH_2)_{16}} \mathrm{COO}\left(\mathrm{CH_2} \mathrm{CH_2} \mathrm{O}\right)_n \mathrm{CH_2} \mathrm{CH_2} \mathrm{OH}$
Liquid dishwashing detergents are non-ionic type. Mechanism of cleansing action of this type of detergents is the same as that of soaps. These also remove grease and oil by micelle formation.
Main problem that appears in the use of detergents is that if their hydrocarbon chain is highly branched, then bacteria cannot degrade this easily. Slow degradation of detergents leads to their accumulation. Effluents containing such detergents reach the rivers, ponds, etc. These persist in water even after sewage treatment and cause foaming in rivers, ponds and streams and their water gets polluted.
These days the branching of the hydrocarbon chain is controlled and kept to the minimum. Unbranched chains can be biodegraded more easily and hence pollution is prevented.
Exercises
Intext Question
16.4 Write the chemical equation for preparing sodium soap from glyceryl oleate and glyceryl palmitate. Structural formulae of these compounds are given below.
(i) $\left(\mathrm{C_15} \mathrm{H_31} \mathrm{COO}\right)_{3} \mathrm{C_3} \mathrm{H_5}$ - Glyceryl palmitate
(ii) $\left(\mathrm{C_17} \mathrm{H_32} \mathrm{COO}\right)_{3} \mathrm{C_3} \mathrm{H_5}$ - Glyceryl oleate
Answer (i) (ii)
Show Answer
Show Answer
Answer
Functional groups present in the molecule are:
(i) Ether, and
(ii) primary alcoholic group
Summary
Chemistry is essentially the study of materials and the development of new materials for the betterment of humanity. A drug is a chemical agent, which affects human metabolism and provides cure from ailment. If taken in doses higher than recommended, these may have poisonous effect. Use of chemicals for therapeutic effect is called chemotherapy. Drugs usually interact with biological macromolecules such as carbohydrates, proteins, lipids and nucleic acids. These are called target molecules. Drugs are designed to interact with specific targets so that these have the least chance of affecting other targets. This minimises the side effects and localises the action of the drug. Drug chemistry centres around arresting microbes/destroying microbes, preventing the body from various infectious diseases, releasing mental stress, etc. Thus, drugs like analgesics, antibiotics, antiseptics, disinfectants, antacids and tranquilizers are used for specific purpose. To check the population explosion, antifertility drugs have also become prominent in our life.
Food additives such as preservatives, sweetening agents, flavours, antioxidants, edible colours and nutritional supplements are added to the food to make it attractive, palatable and add nutritive value. Preservatives are added to the food to prevent spoilage due to microbial growth. Artificial sweeteners are used by those who need to check the calorie intake or are diabetic and want to avoid taking sucrose.
These days, detergents are much in vogue and get preference over soaps because they work even in hard water. Synthetic detergents are classified into three main categories, namely: anionic, cationic and non-ionic, and each category has its specific uses. Detergents with straight chain of hydrocarbons are preferred over branched chain as the latter are non-biodegradable and consequently cause environmental pollution.
Exercises
16.1 Why do we need to classify drugs in different ways?
Answer The classification of drugs and the reasons for classification are as follows: (i) On the basis of pharmacological effect: This classification provides doctors the whole range of drugs available for the treatment of a particular type of problem. Hence, such a classification is very useful to doctors. (ii) On the basis of drug action: This classification is based on the action of a drug on a particular biochemical process. Thus, this classification is important. (iii) On the basis of chemical structure: This classification provides the range of drugs sharing common structural features and often having similar pharmacological activity. (iv) On the basis of molecular targets: This classification provides medicinal chemists the drugs having the same mechanism of action on targets. Hence, it is the most useful to medicinal chemists.Show Answer
Answer In medicinal chemistry, drug targets refer to the key molecules involved in certain metabolic pathways that result in specific diseases. Carbohydrates, proteins, lipids, and nucleic acids are examples of drug targets. Drugs are chemical agents designed to inhibit these target molecules by binding with the active sites of the key molecules.Show Answer
Answer The macromolecules chosen as drug targets are carbohydrates, lipids, proteins, and nucleic acids.Show Answer
Answer A medicine can bind to more than one receptor site. Thus, a medicine may be toxic for some receptor sites. Further, in most cases, medicines cause harmful effects when taken in higher doses than recommended. As a result, medicines may be poisonous in such cases. Hence, medicines should not be taken without consulting doctors.Show Answer
Answer The use of chemicals for therapeutic effect is called chemotherapy.For example: the use of chemicals in the diagnosis, prevention, and treatment of diseasesShow Answer
Answer Either of the following forces can be involved in holding drugs to the active sites of enzymes. (i) lonic bonding (ii) Hydrogen bonding (iii) Dipole - dipole interaction (iv) van der Waals forceShow Answer
Answer Specific drugs affect particular receptors. Antacids and anti-allergic drugs work on different receptors. This is the reason why antacids and anti-allergic drugs do not interfere with each other’s functions, but interfere with the functions of histamines.Show Answer
Answer Anti-depressant drugs are needed to counteract the effect of depression. These drugs inhibit enzymes catalysing the degradation of the neurotransmitter, noradrenaline. As a result, the important neurotransmitter is slowly metabolised and then it can activate its receptor for longer periods of time. Two anti-depressant drugs are: (i) Iproniazid (ii) PhenelzineShow Answer
Answer Antibiotics that are effective against a wide range of gram-positive and gram-negative bacteria are known as broad spectrum antibiotics. Chloramphenicol is a broad spectrum antibiotic. It can be used for the treatment of typhoid, dysentery, acute fever, pneumonia, meningitis, and certain forms of urinary infections. Two other broad spectrum antibiotics are vancomycin and ofloxacin. Ampicillin and amoxicillin synthetically modified from penicillin - are also broad spectrum antibiotics.Show Answer
Answer Antisepticsand disinfectants are effective against micro-organisms. However, antiseptics are applied to the living tissues such as wounds, cuts, ulcers, and diseased skin surfaces, while disinfectants are applied to inanimate objects such as floors, drainage system, instruments, etc. Disinfectants are harmful to the living tissues. lodine is an example of a strong antiseptic. Tincture of iodine (2 - 3 percent of solution of iodine in alcohol - water mixture) is applied to wounds. 1 percent solution of phenol is used as a disinfectant.Show Answer
Answer Antacids such as sodium hydrogen carbonate, magnesium hydroxide, and aluminium hydroxide work by neutralising the excess hydrochloric acid present in the stomach. However, the root cause for the release of excess acid remains untreated. Cimetidine and rantidine are better antacids as they control the root cause of acidity. These drugs prevent the interaction of histamine with the receptors present in the stomach walls. Consequently, there is a decrease in the amount of acid released by the stomach. This is why cimetidine and rantidine are better antacids than sodium hydrogen carbonate, magnesium hydroxide, and aluminium hydroxide.Show Answer
Answer Phenol can be used as an antiseptic as well as a disinfectant. 0.2 percent solution of phenol is used as an antiseptic, while 1 per cent of its solution is used as a disinfectant.Show Answer
Answer The main constituents of dettol are chloroxylenol and $\alpha$-terpineol.Show Answer
Answer Tincture of iodine is a 2 - 3 percent solution of iodine in alcohol - water mixture. It is applied to wounds as an antiseptic.Show Answer
Answer Food preservatives are chemicals that prevent food from spoilage due to microbial growth. Table salt, sugar, vegetable oil, sodium benzoate $\left(\mathrm{C_6} \mathrm{H_3} \mathrm{COONa}\right)$, and salts of propanoic acid are some examples of food preservatives.Show Answer
Answer Aspartame becomes unstable at cooking temperature. This is the reason why its use is limited to cold foods and drinks.Show Answer
Answer Artificial sweetening agents are chemicals that sweeten food. However, unlike natural sweeteners, they do not add calories to our body. They do not harm the human body. Some artificial sweeteners are aspartame, saccharin, sucrolose, and alitame.Show Answer
Answer Artificial sweetening agents such as saccharin, alitame, and aspartame can be used in preparing sweets for diabetic patients.Show Answer
Answer Alitame is a high potency sweetener. It is difficult to control the sweetness of food while using alitame as an artificial sweetener.Show Answer
Answer Soaps work in soft water. However, they are not effective in hard water. In contrast, synthetic detergents work both in soft water and hard water. Therefore, synthetic detergents are better than soaps.Show Answer
(i) cationic detergents
(ii) anionic detergents and
(iii) non-ionic detergents.
Answer (i) Cationic detergent Cationic detergents are quaternary ammonium salts of acetates, chlorides, or bromides. These are called cationic detergents because the cationic part of these detergents contains a long hydrocarbon chain and a positive charge on the $\mathrm{N}$ atom. For example: cetyltrimethylammonium bromide (ii) Anionic detergents Anionic detergents are of two types: 1. Sodium alkyl sulphates: These detergents are sodium salts of long chain alcohols. They are prepared by first treating these alcohols with concentrated sulphuric acid and then with sodium hydroxide. Examples of these detergents include sodium lauryl sulphate $\left(\mathrm{C_{11}} \mathrm{H_{23}} \mathrm{CH_2} \mathrm{OSO_3} \mathrm{Na}^{+}\right)$ and sodium stearyl sulphate $\left(\mathrm{C_{17}} \mathrm{H_{35}} \mathrm{CH_2} \mathrm{OSO_3} \mathrm{Na}^{+}\right)$. 2. Sodium alkylbenzenesulphonates: These detergents are sodium salts of long chain alkylbenzenesulphonic acids. They are prepared by Friedel-Crafts alkylation of benzene with long chain alkyl halides or alkenes. The obtained product is first treated with concentrated sulphuric acid and then with sodium hydroxide. Sodium 4-(1-dodecy) benzenesulphonate (SDS) is an example of anionic detergents. (iii) Non-ionic detergents Molecules of these detergents do not contain any ions. These detergents are esters of alcohols having high molecular mass. They are obtained by reacting polyethylene glycol and stearic acid.Show Answer
Answer Detergents that can be degraded by bacteria are called biodegradable detergents. Such detergents have straight hydrocarbon chains. For example: sodium lauryl sulphate Detergents that cannot be degraded by bacteria are called non-biodegradable detergents. Such detergents have highly-branched hydrocarbon chains. For example: sodium -4- (1, 3, 5, 7- tetra methyl octyl) benzene sulphonateShow Answer
Answer Soaps are sodium or potassium salts of long-chain fatty acids. Hard water contains calcium and magnesium ions. When soaps are dissolved in hard water, these ions displace sodium or potassium from their salts and form insoluble calcium or magnesium salts of fatty acids. These insoluble salts separate as scum. $
\underset{\text{Soap}}{2 \mathrm{C_{17}} \mathrm{H_{35}} \mathrm{COONa}+\mathrm{CaCl_2}} \longrightarrow 2 \mathrm{NaCl}+ \underset{\substack{\text{Isoluble calcium stearate}\\ \text{(soap)}}}{\left(\mathrm{C_{17}} \mathrm{H_{35}} \mathrm{COO}\right)_{2} \mathrm{Ca}}
$ This is the reason why soaps do not work in hard water.Show Answer
Answer Soaps get precipitated in hard water, but not in soft water. Therefore, soaps can be used for checking the hardness of water. However,synthetic detergents do not get precipitated either in hard water or in soft water. Therefore, synthetic detergents cannot be used for checking the hardness of water.Show Answer
Answer Soap molecules form micelles around an oil droplet (dirt) in such a way that the hydrophobic parts of the stearate ions attach themselves to the oil droplet and the hydrophilic parts project outside the oil droplet. Due to the polar nature of the hydrophilic parts, the stearate ions (along with the dirt) are pulled into water, thereby removing the dirt from the cloth.Show Answer
Answer Synthetic detergents are preferred for cleaning clothes. When soaps are dissolved in water containing calcium ions, these ions form insoluble salts that are of no further use. However, when synthetic detergents are dissolved in water containing calcium ions, these ions form soluble salts that act as cleansing agents.Show Answer
(i) $\mathrm{CH_3}\left(\mathrm{CH_2}\right)_{10} \mathrm{CH_2} \mathrm{OSO_3} \stackrel{-}{\mathrm{Na}}$
(ii) $\mathrm{CH_3}\left(\mathrm{CH_2}\right)_{15} \stackrel{+}{\mathrm{N}}\left(\mathrm{CH_3}\right)_3 \stackrel{-}{\mathrm{Br}}$
(iii) $\mathrm{CH_3}\left(\mathrm{CH_2}\right)_{16} \mathrm{COO}\left(\mathrm{CH_2} \mathrm{CH_2} \mathrm{O}\right)_n \mathrm{CH_2} \mathrm{CH_2} \mathrm{OH}$
Show Answer
Answer
$\underbrace{\mathrm{CH} _3\left(\mathrm{CH} _2\right) _{10} \mathrm{CH} _2} _{\text {Hydrophobic }} \quad \underbrace{\mathrm{O} \mathrm{SO} _3^{-} \mathrm{Na}^{+}} _{\text {Hydrophilic }}$
$\underbrace{\mathrm{CH} _3\left(\mathrm{CH} _2\right) _{15}} _{\text {Hydrophobic }} \quad \underbrace{\mathrm{N}^{+}\left(\mathrm{CH} _3\right) _3 \mathrm{Br}^{-}} _{\text {Hydrophilic }}$
$\underbrace{\mathrm{CH} _3\left(\mathrm{CH} _2\right) _{16}} _{\text {Hydrophobic }} \quad \underbrace{\mathrm{COO}\left(\mathrm{CH} _2 \mathrm{CH} _2 \mathrm{O}\right) _n \mathrm{CH} _2 \mathrm{CH} _2 \mathrm{OH}} _{\text {Hydrophilic }}$
