Carboxylic Acids and their Derivatives - Result Question 69
####55. Arrange the following in order of their increasing ease of hydrolysis :
$(1986,1 M)$
$$ CH _3 COOC _2 H _5, CH _3 COCl,\left(CH _3 CO\right) _2 O, CH _3 CONH _2 $$
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Solution:
- Among acid derivatives, the reactivity towards nucleophilic acyl substitution is in the order of :
Amide $<$ Ester $<$ Anhydride $<$ Acid chloride Hydrolysis is an example of nucleophilic acyl substitution, hence the reactivity towards hydrolysis is :
$CH _3 CONH _2<CH _3 COOC _2 H _5<\left(CH _3 CO\right) _2 O<CH _3 COCl$
