Genetics And Evolution Evolution Factors
Evolution - Factors
Factors influencing evolution
Mutation
Gene flow
Genetic drift
Natural selection
Non-random mating
Genetics And Evolution Evolution Factors
Mutation
Introduction of genetic variation
Can be beneficial, harmful, or neutral
Example: Sickle cell anemia
Genetics And Evolution Evolution Factors
Gene flow
Movement of genes from one population to another
Can increase genetic diversity
Example: Migration of birds
Genetics And Evolution Evolution Factors
Genetic drift
Random changes in gene frequency due to chance events
More pronounced in small populations
Example: Founder effect
Genetics And Evolution Evolution Factors
Natural selection
Differential survival and reproduction of individuals with certain traits
Leads to adaptation
Example: Peppered moth
Genetics And Evolution Evolution Factors
Non-random mating
Selection of mates based on certain traits
Can lead to sexual selection
Example: Peacock feathers selection
Genetics And Evolution Evolution Factors
Genetics and Evolution - Types of Evolution
Divergent evolution
Species evolve from a common ancestor and become more different over time
Example: Darwin’s finches
Convergent evolution
Unrelated species evolve similar traits due to similar environments
Example: Wings in bats and birds
Genetics And Evolution Evolution Factors
Genetics and Evolution - Types of Evolution
Coevolution
Two or more species evolve in response to each other
Example: Flowering plants and their pollinators
Parallel evolution
Related species independently evolve similar traits
Example: Marsupials in Australia and placental mammals in other continents
Adaptive radiation
Rapid diversification of a single ancestral species into multiple new species
Example: Galapagos finches
Genetics And Evolution Evolution Factors
Genetics and Evolution - Speciation
Speciation
Formation of new species from an existing species
Allopatric speciation
Geographic isolation leads to speciation
Example: Islands and mainland populations
Sympatric speciation
Speciation occurs without geographic isolation
Example: Polyploidy in plants
Genetics And Evolution Evolution Factors
Genetics and Evolution - Speciation
Reproductive isolation
Barriers prevent members of different species from mating
Example: Temporal isolation
Types of reproductive isolation
Prezygotic barriers
Temporal, ecological, behavioral, mechanical, and gametic barriers
Postzygotic barriers
Reduced hybrid viability, reduced hybrid fertility, and hybrid breakdown
Genetics And Evolution Evolution Factors
Genetics and Evolution - Hardy-Weinberg Principle
Hardy-Weinberg principle
Describes the genetic equilibrium in a population that is not evolving
Conditions for Hardy-Weinberg equilibrium
Large population size
No migration
No mutation
Random mating
No natural selection
Hardy-Weinberg equation
p^2 + 2pq + q^2 = 1
Genetics And Evolution Evolution Factors
Application of the Hardy-Weinberg principle
Estimating allele frequencies
Determining if the population is evolving
Genetics And Evolution Evolution Factors
Genetics and Evolution - Genetic Variation
Genetic variation
Differences in the genetic makeup of individuals in a population
Causes of genetic variation
Mutation
Recombination through sexual reproduction
Genetics And Evolution Evolution Factors
Importance of genetic variation
Provides raw material for evolution
Increases the chances of survival of a population in changing environments
Genetics And Evolution Evolution Factors
Sources of genetic variation
Sexual reproduction
Gene flow
Mutation
Genetics And Evolution Evolution Factors
Genetics and Evolution - Human Evolution
Human evolution
Studying the evolutionary history of humans and our ancestors
Homo sapiens
Modern humans belong to the species Homo sapiens
Hominins
Group of species including modern humans and our close relatives
Examples: Homo neanderthalensis, Homo erectus
Genetics And Evolution Evolution Factors
Genetics and Evolution - Human Evolution
Origins of humans
African hypothesis suggests humans evolved in Africa and migrated to other continents
Fossil evidence
Fossils provide evidence of our evolutionary history
Example: Lucy, a famous Australopithecus afarensis fossil
Genetics And Evolution Evolution Factors
Genetics and Evolution - Genetic Disorders
Genetic disorders
Diseases caused by abnormalities in an individual’s DNA
Types of genetic disorders
Single gene disorders
Caused by mutations in a single gene
Example: Cystic fibrosis
Chromosomal disorders
Caused by changes in the number or structure of chromosomes
Example: Down syndrome
Genetics And Evolution Evolution Factors
Genetics and Evolution - Genetic Disorders
Types of genetic disorders
Multifactorial disorders
Caused by a combination of genetic and environmental factors
Example: Heart disease, diabetes
Mitochondrial disorders
Caused by mutations in the mitochondrial DNA
Example: Mitochondrial encephalomyopathy
Genetics And Evolution Evolution Factors
Genetics and Evolution - Genetic Engineering
Genetic engineering
Manipulating an organism’s DNA to produce desired traits
Steps in genetic engineering
Isolation of the target gene
Insertion of the gene into a vector
Transformation of the host organism
Selection and characterization of transformed organisms
Genetics And Evolution Evolution Factors
Applications of genetic engineering
Crop improvement through genetic modification
Production of recombinant proteins
Gene therapy for treating genetic disorders
Creating genetically modified organisms (GMOs)
Genetics And Evolution Evolution Factors
Genetics and Evolution - Cloning
Cloning
Production of genetically identical copies of an organism
Types of cloning
Reproductive cloning
Produces a clone of an entire organism
Example: Dolly the sheep
Therapeutic cloning
Produces embryonic stem cells for medical research
Does not result in the birth of a cloned organism
Ethics of cloning
Cloning raises ethical concerns about the manipulation of life
Regulation is necessary to ensure responsible use of cloning technology
Genetics And Evolution Evolution Factors
Genetics and Evolution - Gene Therapy
Gene therapy
Treating genetic disorders by introducing functional genes into damaged cells
Types of gene therapy
Somatic gene therapy
Targeting non-reproductive cells to treat the individual
Does not affect future generations
Germline gene therapy
Modifying reproductive cells or early embryos to pass on genetic changes to future generations
Not currently performed in humans due to ethical concerns
Genetics And Evolution Evolution Factors
Challenges in gene therapy
Efficient and targeted delivery of genes
Long-term expression of the inserted genes
Potential risks and side effects
Genetics And Evolution Evolution Factors
Genetics and Evolution - Genetic Testing
Genetic testing
Analyzing an individual’s DNA to detect genetic abnormalities or assess disease risk
Types of genetic testing
Diagnostic testing
Identifying the genetic cause of a disease in an individual
Carrier testing
Assessing the risk of passing on a genetic disorder to offspring
Predictive testing
Identifying the risk of developing a disease in the future
Prenatal testing
Detecting genetic abnormalities in a fetus during pregnancy
Genetics And Evolution Evolution Factors
Benefits and limitations of genetic testing
Provides valuable information for medical intervention and family planning
Some genetic tests have limitations in accuracy and interpretation
Genetics And Evolution Evolution Factors
Genetics and Evolution - Genetic Disorders and Inheritance Patterns
Inheritance patterns of genetic disorders
Autosomal dominant
Disorders caused by a dominant allele on an autosomal chromosome
Example: Huntington’s disease
Autosomal recessive
Disorders caused by two recessive alleles on an autosomal chromosome
Example: Cystic fibrosis
Genetics And Evolution Evolution Factors
Genetics and Evolution - Genetic Disorders and Inheritance Patterns
Inheritance patterns of genetic disorders
X-linked recessive
Disorders caused by a recessive allele on the X chromosome
Example: Hemophilia
X-linked dominant
Disorders caused by a dominant allele on the X chromosome
Example: Vitamin D-resistant rickets
Y-linked
Disorders caused by mutations on the Y chromosome
Example: Male infertility
Genetics And Evolution Evolution Factors
Genetics and Evolution - Sex Determination
Sex determination in humans
XX for females, XY for males
Sex-linked traits
Traits controlled by genes on the sex chromosomes
Example
: Color blindness, hemophilia
Genetics And Evolution Evolution Factors
Genetics and Evolution - Genetic Polymorphisms
Genetic polymorphisms
Variations in DNA sequence that occur at a frequency greater than 1% in a population
Single nucleotide polymorphisms (SNPs)
Single base pair changes in DNA sequence
Copy number variations (CNVs)
Changes in the number of copies of a particular DNA segment
Insertions, deletions, and inversions
Structural variations in DNA sequence
Genetics And Evolution Evolution Factors
Importance of genetic polymorphisms
Can be used as markers for genetic mapping and studies of human evolution
Some polymorphisms have functional implications, affecting phenotype and disease risk
Genetics And Evolution Evolution Factors
Genetics and Evolution - Genetic Engineering Techniques
Genetic engineering techniques
Polymerase chain reaction (PCR)
Amplification of specific DNA fragments
DNA sequencing
Determining the order of nucleotide bases in a DNA molecule
Restriction enzymes
Cutting DNA at specific recognition sites
Gel electrophoresis
Separation of DNA fragments based on size
Recombinant DNA technology
Joining of DNA from different sources
Genetics And Evolution Evolution Factors
Genetics and Evolution - Human Genome Project
Human Genome Project (HGP)
International scientific research project to sequence and map the entire human genome
Goals of the HGP
Determine the sequence of nucleotide base pairs in human DNA
Identify and map all genes in the genome
Genetics And Evolution Evolution Factors
Implications of the HGP
Advancements in personalized medicine
Understanding genetic basis of diseases
Ethical and legal considerations
Genetics And Evolution Evolution Factors
Genetics and Evolution - DNA Fingerprinting
DNA fingerprinting
Analyzing genetic material to identify individuals
Steps in DNA fingerprinting
DNA extraction from a sample
Amplification of specific DNA regions using PCR
Separation of DNA fragments by gel electrophoresis
Comparison of DNA banding patterns
Genetics And Evolution Evolution Factors
Applications of DNA fingerprinting
Forensic investigations
Paternity and maternity testing
Identification of human remains
Wildlife conservation
Genetics And Evolution Evolution Factors
Genetics and Evolution - Conservation Genetics
Conservation genetics
Application of genetic methods to study and protect threatened species
Genetic factors influencing conservation
Genetic diversity
Inbreeding
Genetic drift
Genetics And Evolution Evolution Factors
Techniques in conservation genetics
DNA barcoding
Population genetics analysis
Genetics And Evolution Evolution Factors
Conservation genetics in action
Determining population size and structure
Identifying source populations for translocations
Assessing risks of inbreeding and genetic disease
Genetics And Evolution Evolution Factors
Genetics and Evolution - Epigenetics
Epigenetics
Study of heritable changes in gene expression that do not involve changes to the underlying DNA sequence
Epigenetic mechanisms
DNA methylation
Histone modifications
Non-coding RNAs
Genetics And Evolution Evolution Factors
Implications of epigenetics
Influence on development, aging, and disease
Role in understanding phenotypic variation and heritability
Potential for epigenetic therapies
Genetics And Evolution Evolution Factors
Genetics and Evolution - Stem Cells
Stem cells
Undifferentiated cells capable of self-renewal and differentiation into specialized cell types
Types of stem cells
Embryonic stem cells
Adult stem cells
Hematopoietic stem cells
Mesenchymal stem cells
Genetics And Evolution Evolution Factors
Applications of stem cells
Regenerative medicine
Disease modeling
Drug testing
Ethical considerations
Genetics And Evolution Evolution Factors
Genetics and Evolution - Gene Regulation
Gene regulation
Processes that control the expression of genes
Regulation of gene expression
Transcriptional regulation
Post-transcriptional regulation
Translational regulation
Post-translational regulation
Genetics And Evolution Evolution Factors
Importance of gene regulation
Ensures proper development and function of organisms
Enables cells to respond to environmental cues
Dysregulation can lead to diseases like cancer