Biomolecules Hydrogen Bonding Dictates Base Pairing
Introduction to Biomolecules
Biomolecules are the organic molecules that are essential for life.
They are mainly composed of carbon, hydrogen, oxygen, nitrogen, phosphorus, and sulfur.
Biomolecules include carbohydrates, lipids, proteins, and nucleic acids.
These molecules play vital roles in various biological processes.
They are responsible for storing and transforming energy, providing structure, and carrying out chemical reactions.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Carbohydrates
Carbohydrates are organic compounds composed of carbon, hydrogen, and oxygen.
They are classified as monosaccharides, disaccharides, and polysaccharides.
Monosaccharides are the simplest carbohydrates, such as glucose, fructose, and galactose.
Disaccharides are formed by the condensation of two monosaccharide units, for example, sucrose and lactose.
Polysaccharides are complex carbohydrates, like cellulose, starch, and glycogen.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Lipids
Lipids are a diverse group of biomolecules that are insoluble in water.
They are composed of carbon, hydrogen, and oxygen.
Lipids include fats, oils, phospholipids, and steroids.
Fats and oils are triglycerides and provide energy storage.
Phospholipids are important components of cell membranes.
Steroids are involved in various biological functions, such as hormone production.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Proteins
Proteins are large biomolecules composed of amino acids.
They have diverse functions, including enzyme catalysis, structural support, and transport.
Amino acids are linked together by peptide bonds to form polypeptide chains.
Proteins have a specific three-dimensional structure
: primary, secondary, tertiary, and quaternary.
Examples of proteins include enzymes, antibodies, and structural proteins like collagen.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Nucleic Acids
Nucleic acids are the genetic material of living organisms.
They are composed of nucleotides, which consist of a sugar, a phosphate group, and a nitrogenous base.
There are two types of nucleic acids
: DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
DNA carries the genetic information and is double-stranded, while RNA is involved in protein synthesis and is usually single-stranded.
The base pairing between adenine-thymine (DNA) or adenine-uracil (RNA) and cytosine-guanine is essential for their function.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Hydrogen Bonding
Hydrogen bonding is a type of intermolecular force that occurs between molecules containing a hydrogen atom bonded to a highly electronegative atom like oxygen or nitrogen.
In biomolecules, hydrogen bonding plays a crucial role, especially in protein and nucleic acid structures.
It dictates base pairing in DNA and RNA, resulting in the complementary pairing of nucleotides.
Hydrogen bonds are weaker than covalent bonds but important for maintaining the overall structure and stability of biomolecules.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Carbohydrates - Functions
Carbohydrates serve as an important energy source for the body.
They provide quick energy to cells through cellular respiration.
Carbohydrates also play a role in cell structure, such as cellulose in plant cell walls and chitin in the exoskeleton of insects.
Some carbohydrates, like glycogen, serve as energy storage molecules in animals.
Blood groups are determined by specific carbohydrate molecules present on red blood cell surfaces.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Lipids - Functions
Lipids are an efficient long-term energy storage form in the body.
They provide insulation and protection to vital organs.
Lipids are important components of cell membranes, maintaining their structure and fluidity.
Some lipids act as signaling molecules, like hormones.
They also serve as precursors for the synthesis of various biomolecules, including steroids and bile acids.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Proteins - Functions
Proteins are involved in enzyme catalysis, speeding up chemical reactions in cells.
They provide structural support to cells, tissues, and organs.
Proteins are responsible for transport, such as the movement of molecules across cell membranes.
Antibodies, a type of protein, help in immune response and defense against pathogens.
Proteins also regulate gene expression and act as molecular switches in signal transduction pathways.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Nucleic Acids - Functions
Nucleic acids are responsible for storing and transmitting genetic information.
DNA contains the instructions for protein synthesis.
RNA plays a crucial role in translating the genetic code into proteins.
Nucleic acids are involved in the replication and repair of genetic material.
They regulate gene expression and control various cellular processes.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Biomolecules - Hydrogen Bonding Dictates Base Pairing
Hydrogen bonding is crucial in determining base pairing in nucleic acids.
DNA: Adenine (A) forms two hydrogen bonds with Thymine (T), and Guanine (G) forms three hydrogen bonds with Cytosine (C).
RNA: Adenine (A) forms two hydrogen bonds with Uracil (U), and Guanine (G) forms three hydrogen bonds with Cytosine (C).
Base pairing allows for the complementary sequence of nucleotides in DNA and RNA.
Hydrogen bonds between base pairs hold the two strands of DNA together in a double helix structure.
The specific base pairing is essential for DNA replication, transcription, and translation.
Disruption in base pairing can lead to genetic mutations and diseases.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Carbohydrates - Monosaccharides
Monosaccharides are the simplest carbohydrates, consisting of a single sugar unit.
Examples of monosaccharides include glucose, fructose, and galactose.
Glucose is the primary energy source for cells and is crucial for cellular respiration.
Fructose is found in fruits and is often used in sweeteners.
Galactose is a component of lactose, the sugar found in milk.
Monosaccharides are easily absorbed and transported in the body.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Carbohydrates - Disaccharides
Disaccharides are formed by the condensation of two monosaccharide units.
Examples of disaccharides include sucrose, lactose, and maltose.
Sucrose is commonly known as table sugar and is composed of glucose and fructose.
Lactose is found in milk and consists of glucose and galactose.
Maltose is a product of starch digestion and is made up of two glucose molecules.
Disaccharides are broken down into monosaccharides during digestion.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Carbohydrates - Polysaccharides
Polysaccharides are complex carbohydrates composed of many monosaccharide units.
Examples of polysaccharides include cellulose, starch, and glycogen.
Cellulose is the main component of plant cell walls and provides structural support.
Starch is the storage form of glucose in plants and can be broken down for energy.
Glycogen is the storage form of glucose in animals and is mainly stored in the liver and muscles.
Polysaccharides serve as a long-term energy reserve in organisms.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Lipids - Fats and Oils
Fats and oils are the primary types of lipids.
They are composed of fatty acids and glycerol.
Fats are solid at room temperature, while oils are liquid.
Fats are found in animals, while oils are mainly derived from plants.
Fats and oils serve as a concentrated and long-term energy source for the body.
They provide insulation and cushioning to protect vital organs.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Lipids - Phospholipids
Phospholipids are a major component of cell membranes.
They are composed of a glycerol backbone, two fatty acid chains, and a phosphate group.
Phospholipids have a hydrophilic head (phosphate group) and hydrophobic tails (fatty acid chains).
The hydrophobic tails align together, forming the interior of the lipid bilayer.
The hydrophilic heads face outward and interact with water on both sides of the cell membrane.
Phospholipids play a crucial role in maintaining the structure and integrity of cell membranes.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Lipids - Steroids
Steroids are a class of lipids with a specific carbon skeleton arrangement.
They have multiple rings fused together, such as cholesterol and hormones like estrogen and testosterone.
Cholesterol is an essential component of cell membranes and is a precursor for steroid hormone synthesis.
Steroid hormones are involved in various physiological processes, including growth, development, and reproduction.
Steroids can have both beneficial and harmful effects on the body depending on their role and level of regulation.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Proteins - Amino Acids
Proteins are composed of amino acids, which are the building blocks of proteins.
Amino acids contain an amino group, a carboxyl group, a hydrogen atom, and a side chain (R-group).
There are 20 different amino acids that can combine in various sequences to form different proteins.
Each amino acid has a unique R-group that determines its chemical properties and function.
The sequence of amino acids in a protein determines its structure and function.
Examples of amino acids include glycine, alanine, and valine.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Proteins - Primary Structure
The primary structure of a protein refers to the sequence of amino acids in a polypeptide chain.
The sequence is determined by the DNA sequence and is essential for protein folding and function.
Even a slight change in the amino acid sequence can significantly impact protein structure and function.
Genetic mutations can lead to alterations in the primary structure, resulting in diseases and disorders.
The primary structure acts as a foundation for the higher levels of protein organization.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Proteins - Secondary, Tertiary, and Quaternary Structures
Secondary structure refers to the local folding of the polypeptide chain into specific patterns.
Common secondary structures include alpha helix and beta sheet.
These structures are stabilized by hydrogen bonding between the amino acid backbone.
Tertiary structure is the overall three-dimensional conformation of a single polypeptide chain.
It is determined by interactions between amino acid side chains, including hydrogen bonding, disulfide bonds, and hydrophobic interactions.
Quaternary structure refers to the arrangement of multiple polypeptide chains to form a functional protein molecule.
Interactions between subunits, such as hydrogen bonding and hydrophobic interactions, stabilize the quaternary structure.
The specific structure of a protein is crucial for its proper function.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Biomolecules - Hydrogen Bonding Dictates Base Pairing
Hydrogen bonding is crucial in determining base pairing in nucleic acids.
Base pairing allows for the complementary sequence of nucleotides in DNA and RNA.
Disruption in base pairing can lead to genetic mutations and diseases.
Examples
:
DNA: Adenine (A) forms two hydrogen bonds with Thymine (T) and Guanine (G) forms three hydrogen bonds with Cytosine (C).
RNA: Adenine (A) forms two hydrogen bonds with Uracil (U) and Guanine (G) forms three hydrogen bonds with Cytosine (C).
Hydrogen bonds between base pairs hold the two strands of DNA together in a double helix structure.
The specific base pairing is essential for DNA replication, transcription, and translation.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Carbohydrates - Monosaccharides
Monosaccharides are the simplest carbohydrates, consisting of a single sugar unit.
Examples
:
Glucose: Primary energy source for cells, involved in cellular respiration.
Fructose: Found in fruits and used in sweeteners.
Galactose: Component of lactose, the sugar found in milk.
Monosaccharides are easily absorbed and transported in the body.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Carbohydrates - Disaccharides
Disaccharides are formed by the condensation of two monosaccharide units.
Examples
:
Sucrose: Table sugar, composed of glucose and fructose.
Lactose: Found in milk, consists of glucose and galactose.
Maltose: Product of starch digestion, made up of two glucose molecules.
Disaccharides are broken down into monosaccharides during digestion.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Carbohydrates - Polysaccharides
Polysaccharides are complex carbohydrates composed of many monosaccharide units.
Examples
:
Cellulose: Main component of plant cell walls, provides structural support.
Starch: Storage form of glucose in plants, broken down for energy.
Glycogen: Storage form of glucose in animals, mainly stored in the liver and muscles.
Polysaccharides serve as a long-term energy reserve in organisms.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Lipids - Fats and Oils
Fats and oils are the primary types of lipids.
They are composed of fatty acids and glycerol.
Fats are solid at room temperature, while oils are liquid.
Fats are found in animals, while oils are mainly derived from plants.
Fats and oils serve as a concentrated and long-term energy source for the body.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Lipids - Phospholipids
Phospholipids are a major component of cell membranes.
They are composed of a glycerol backbone, two fatty acid chains, and a phosphate group.
Phospholipids have a hydrophilic head (phosphate group) and hydrophobic tails (fatty acid chains).
The hydrophobic tails align together, forming the interior of the lipid bilayer.
The hydrophilic heads face outward and interact with water on both sides of the cell membrane.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Lipids - Steroids
Steroids are a class of lipids with a specific carbon skeleton arrangement.
They have multiple rings fused together, such as cholesterol and hormones like estrogen and testosterone.
Cholesterol
: Essential component of cell membranes, precursor for steroid hormone synthesis.
Steroid hormones
: Involved in various physiological processes, including growth, development, and reproduction.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Proteins - Amino Acids
Proteins are composed of amino acids, which are the building blocks of proteins.
Amino acids contain an amino group, a carboxyl group, a hydrogen atom, and a side chain (R-group).
There are 20 different amino acids that can combine in various sequences to form different proteins.
Each amino acid has a unique R-group that determines its chemical properties and function.
The sequence of amino acids in a protein determines its structure and function.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Proteins - Primary Structure
The primary structure of a protein refers to the sequence of amino acids in a polypeptide chain.
The sequence is determined by the DNA sequence and is essential for protein folding and function.
Even a slight change in the amino acid sequence can significantly impact protein structure and function.
Genetic mutations can lead to alterations in the primary structure, resulting in diseases and disorders.
The primary structure acts as a foundation for the higher levels of protein organization.
Biomolecules Hydrogen Bonding Dictates Base Pairing
Proteins - Secondary, Tertiary, and Quaternary Structures
Secondary structure
: Local folding of the polypeptide chain into specific patterns (alpha helix, beta sheet).
Stabilized by hydrogen bonding between the amino acid backbone.
Tertiary structure
: Overall three-dimensional conformation of a single polypeptide chain.
Determined by interactions between amino acid side chains, including hydrogen bonding, disulfide bonds, and hydrophobic interactions.
Quaternary structure
: Arrangement of multiple polypeptide chains to form a functional protein molecule.
Stabilized by interactions between subunits (hydrogen bonding, hydrophobic interactions).
Specific protein structures are crucial for proper function.