Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Biology in Human Welfare - Human Health and Disease
Introduction to cancer detection & diagnosis
Importance of early detection
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Factors Affecting Cancer Detection
Genetic factors
Exposure to carcinogens
Aging
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Methods of Cancer Detection
Physical examination
Imaging techniques (X-ray, MRI, PET)
Biopsy
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Physical Examination for Cancer Detection
Palpation
Observation of abnormal growth or changes in the body
Examination of lymph nodes
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Imaging Techniques for Cancer Detection
X-ray
: Detects abnormalities in bones and organs
MRI
: Provides detailed images of soft tissues and organs
PET
: Identifies areas of high metabolic activity
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Biopsy for Cancer Detection
Tissue sample collection
Histopathological examination
Types of biopsies
: needle biopsy, surgical biopsy
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Cancer Biomarkers
Definition of biomarkers
Examples
: PSA for prostate cancer, CA-125 for ovarian cancer
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Molecular Techniques for Cancer Detection
Polymerase chain reaction (PCR)
Next-generation sequencing (NGS)
Fluorescence in situ hybridization (FISH)
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Liquid Biopsy
Definition of liquid biopsy
Detection of circulating tumor cells (CTCs) and cell-free DNA (cfDNA)
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Cancer Screening Programs
Importance of screening programs
Examples
: mammography for breast cancer, colonoscopy for colorectal cancer
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Common Types of Cancer
Breast cancer
Lung cancer
Prostate cancer
Colorectal cancer
Skin cancer
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Diagnostic Methods for Breast Cancer
Self-examination
Mammography
Ultrasound
Magnetic resonance imaging (MRI)
Biopsy
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Diagnostic Methods for Lung Cancer
Imaging techniques (X-ray, CT scan)
Sputum cytology
Bronchoscopy
Biopsy (needle or surgical)
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Diagnostic Methods for Prostate Cancer
Digital rectal examination (DRE)
Prostate-specific antigen (PSA) blood test
Transrectal ultrasound
Biopsy (transrectal or transperineal)
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Diagnostic Methods for Colorectal Cancer
Colonoscopy
Fecal occult blood test (FOBT)
Flexible sigmoidoscopy
Virtual colonoscopy
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Diagnostic Methods for Skin Cancer
Visual inspection
Dermoscopy
Biopsy (punch, excisional, or shave)
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Cancer Staging and Grading
TNM system for staging
Grade based on tumor differentiation
Importance of accurate staging and grading in treatment planning
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Molecular Diagnostics in Cancer
Gene expression profiling
Mutation testing (e.g., BRCA1, BRCA2)
Fusion gene detection (e.g., BCR-ABL)
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Liquid Biopsy Applications
Monitoring treatment response
Detection of minimal residual disease
Early detection of relapse or metastasis
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Challenges in Cancer Detection and Diagnosis
False-positive and false-negative results
Overdiagnosis and overtreatment
Accessibility to diagnostic facilities
Cost-effectiveness of diagnostic methods
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Molecular Diagnostics in Cancer (contd.)
Genomic profiling for personalized medicine
Circulating tumor DNA (ctDNA) analysis for mutation detection
MicroRNA expression profiling
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Artificial Intelligence in Cancer Detection
Machine learning algorithms for image analysis
Deep learning techniques for pattern recognition
AI-based algorithms for early detection and diagnosis
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Challenges in Cancer Detection and Diagnosis (contd.)
Limited sensitivity and specificity of diagnostic tests
Lack of universal biomarkers for all types of cancer
Ethical considerations in genomic testing and privacy issues
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Future Directions in Cancer Detection
Liquid biopsy advancements
Development of novel imaging techniques
Integration of molecular and imaging modalities
Big data analytics for improved diagnosis and treatment decisions
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
Summary
Cancer detection is essential for early diagnosis and effective treatment.
Physical examination, imaging techniques, and biopsies are commonly used methods for cancer detection.
Biomarkers, molecular diagnostics, and liquid biopsies have revolutionized cancer detection.
Screening programs play a crucial role in detecting cancer at an early stage.
Molecular diagnostics and AI have the potential to improve cancer detection accuracy.
Biology In Human Welfare Human Health And Disease Cancer Detection Diagnosis
References
National Cancer Institute. (2021). Cancer diagnostics. Retrieved from [https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis](https
://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis](
https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis
)
World Health Organization. (2021). Early detection of cancer. Retrieved from [https://www.who.int/cancer/prevention/diagnosis-screening/early-detection/en/](https
://www.who.int/cancer/prevention/diagnosis-screening/early-detection/en/](
https://www.who.int/cancer/prevention/diagnosis-screening/early-detection/en/
)
Perkel, J. M. (2018). Artificial intelligence takes on disease detection. Nature, 557(7707), S16-S17.
Pantel, K., & Alix-Panabières, C. (2019). Liquid biopsy
: potential and challenges. Molecular oncology, 13(3), 615-617.