Slide 11
- Applications of ribosomal RNA sequencing
- Analysis of rRNA gene sequences for phylogenetic studies
- Identification of microbial communities in environmental samples
- Study of gene expression and RNA processing
- Diagnosis of infectious diseases and genetic disorders
Slide 12
- Ribosomes and antibiotic resistance
- Targeting ribosome components to overcome antibiotic resistance
- Mechanisms of resistance to ribosome-targeting antibiotics
- Examples of ribosomal mutations causing antibiotic resistance
- Implications for antibiotic development and treatment strategies
Slide 13
- Ribosomes and antibiotics in agriculture
- Use of ribosome-targeting antibiotics in animal feed
- Impact on livestock health and growth promotion
- Antibiotic resistance in agricultural settings
- Alternatives to antibiotics in agriculture
Slide 14
- Ribosomes, translation, and gene expression regulation
- Role of ribosomes in regulating gene expression
- Ribosome stalling and the role of small noncoding RNAs
- Ribosome-associated quality control mechanisms
- Link between ribosome function and cellular stress response
Slide 15
- Ribosomes and the molecular clock hypothesis
- Use of ribosomal RNA sequences in molecular clock studies
- Estimating evolutionary relationships and divergence times
- Limitations and challenges in molecular clock analysis
- Insights into evolutionary history and speciation events
Slide 16
- Ribosomes and protein folding
- Role of ribosomes in co-translational protein folding
- Chaperones and their interaction with nascent polypeptides
- Ribosome-associated quality control in protein folding
- Protein misfolding and its implications in disease
Slide 17
- Ribosomes and post-translational modifications
- Role of ribosomes in protein glycosylation
- Importance of ribosomal modifications in protein function
- Disease-associated ribosomal modifications
- Therapeutic potential of targeting ribosomal modifications
Slide 18
- Ribosomes and non-canonical translation
- Ribosome reprogramming during stress responses
- Initiation of translation at non-AUG codons
- Ribosome bypassing and ribosome shunting
- Implications for cellular adaptations and disease
Slide 19
- Ribosomes and mitochondrial function
- Role of ribosomes in mitochondrial protein synthesis
- Differences between mitochondrial and cytoplasmic ribosomes
- Impact of ribosomal defects on mitochondrial disorders
- Therapeutic strategies for mitochondrial ribosomal diseases
Slide 20
- Conclusion and further reading
- Recap of key concepts related to ribosomes
- Additional resources for in-depth study of ribosome biology
- Importance of understanding ribosome function in diverse fields
- Encouragement for further exploration and research in ribosomal biology
Slide 21
- Role of ribosomes in cellular homeostasis
- Maintaining balance between protein synthesis and degradation
- Relationship between ribosomes and proteasome machinery
- Implications in protein quality control and aging
- Regulatory mechanisms for ribosome turnover
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Slide 22
- Ribosomes and stress response pathways
- Activation of ribosome production during stress conditions
- Impact on cellular growth and survival
- Examples of stress-responsive ribosomal genes
- Significance in adaptation and evolution
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Slide 23
- Ribosomes and epigenetic regulation
- Influence of ribosome occupancy on gene expression
- Ribosome-associated chromatin modifications
- Association between ribosomes and histone modifications
- Crosstalk between ribosomes and epigenetic marks
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Slide 24
- Ribosomal RNA modifications and RNA processing
- Importance of ribosomal RNA modifications in ribosome biogenesis
- Examples of ribosomal RNA modifications and their roles
- Implications for RNA processing and post-transcriptional regulation
- Connection to human diseases and developmental disorders
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Slide 25
- Role of ribosomes in viral infections
- Viral takeover of host ribosomes for viral protein synthesis
- Interaction between viral RNA and ribosomes
- Development of antiviral drugs targeting ribosomal proteins
- Emergence of drug-resistant viral strains
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Slide 26
- Ribosomes and gene therapy
- Use of ribosome engineering for gene therapy delivery
- Role of ribosomes in efficient translation of therapeutic genes
- Challenges in optimizing ribosome-mediated gene therapy
- Potential future directions in ribosome-based gene therapy
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Slide 27
- Ribosomes as targets for cancer therapy
- Dysregulation of ribosome biogenesis in cancer cells
- Targeting ribosomal RNA for cancer treatment
- Ribosome-targeting drugs and their mechanism of action
- Potential side effects and limitations of ribosome-targeted cancer therapies
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Slide 28
- Ribosomes in neurodegenerative diseases
- Impaired ribosome function in neurodegenerative disorders
- Relationship between ribosome dysfunction and protein aggregation
- Link between ribosome-associated stress and neuronal cell death
- Therapeutic strategies targeting ribosomes for neuroprotection
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Slide 29
- Emerging techniques in ribosome research
- Cryo-electron microscopy for high-resolution ribosome structure determination
- Ribosome profiling combined with next-generation sequencing technologies
- Single-molecule methods for studying ribosome dynamics
- Integration of computational modeling and simulations in ribosome research
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Slide 30
- Final remarks and Q&A session
- Recap of key points covered in the lecture
- Invitation for questions and discussions
- Resources for further reading and exploration
- Closing remarks and encouragement for continued interest in ribosomal biology