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Genetics and Evolution
Evolution - Biological Evolution
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- Definition of evolution:
- The process of change in all forms of life over generations
- It occurs due to heritable variations and natural selection
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- Theories of evolution:
- Lamarckism
- Darwinism
- Modern Synthetic Theory of Evolution
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- Lamarckism:
- Proposed by Jean-Baptiste Lamarck
- Theory of inheritance of acquired characteristics
- Example: Giraffes developing long necks due to stretching to reach leaves
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- Darwinism:
- Proposed by Charles Darwin
- Theory of natural selection
- Descent with modification
- Example: Finches of Galapagos Islands adapting to different environments
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- Modern Synthetic Theory of Evolution:
- Also known as Neo-Darwinian theory
- Combines ideas of Darwinism and genetics
- Emphasizes the role of mutations and genetic variation
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- Evidences of evolution:
- Fossils
- Comparative anatomy
- Comparative embryology
- Molecular biology
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- Fossils:
- Preserved remains or traces of past organisms
- Provide evidence of extinct species and intermediate forms
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- Comparative anatomy:
- Study of similarities and differences in the structure of organisms
- Homologous structures, vestigial organs, and analogous structures
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- Comparative embryology:
- Study of similarities and differences in the embryonic development of organisms
- Reveals common ancestry and evolutionary relationships
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- Molecular biology:
- Study of molecular structures and processes in living organisms
- DNA sequencing and analysis provide evidence of evolutionary relationships
- Example: Comparing the DNA sequences of different species
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- Hardy-Weinberg principle:
- States that the frequencies of alleles in a population will remain constant if certain conditions are met
- Equilibrium equation: p² + 2pq + q² = 1
- Example: Calculating allele frequencies in a population
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- Genetic drift:
- Random changes in allele frequencies over generations
- More pronounced in small populations
- Example: Founder effect and bottleneck effect
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- Gene flow:
- Transfer of genes between populations through migration and interbreeding
- Increases genetic variation within a population
- Example: Introduction of new genes through migration
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- Mutation:
- Changes in DNA sequence that create new genetic variation
- Can occur spontaneously or due to external factors
- Example: Point mutations and chromosomal mutations
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- Natural selection:
- Process by which advantageous traits become more common in a population
- Acts on variations that provide a selective advantage in a given environment
- Example: Peppered moth and industrial melanism
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- Types of natural selection:
- Stabilizing selection
- Directional selection
- Disruptive selection
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- Stabilizing selection:
- Favors average phenotypes and reduces variation
- Example: Birth weight in humans
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- Directional selection:
- Favors individuals with extreme phenotypes, leading to a shift in the population’s characteristics
- Example: Antibiotic resistance in bacteria
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- Disruptive selection:
- Favors individuals with extreme phenotypes at both ends of the distribution, leading to the formation of two distinct groups
- Example: Beak size in finches
Mechanisms of Evolution
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Mutation:
- Introduces new alleles into a population
- Can be harmful, beneficial, or neutral
- Mutation rate is influenced by various factors
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Gene Flow:
- Transfer of genes between populations due to migration and interbreeding
- Enhances genetic diversity within a population
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Genetic Drift:
- Random changes in allele frequencies due to chance events
- More significant in small populations
- Founder effect and bottleneck effect
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Types of Speciation
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Allopatric Speciation:
- Geographic isolation leads to the formation of new species
- Example: Islands or physical barriers separating populations
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Sympatric Speciation:
- Speciation occurs within the same geographic area
- Due to factors like polyploidy, habitat differentiation, or sexual selection
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Parapatric Speciation:
- Occurs when populations are separated by an extreme change in habitat
- Limited gene flow between populations
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Adaptive Radiation
- Rapid diversification of a single ancestral lineage into various ecological niches
- In response to new environments or evolutionary opportunities
- Example: Galapagos finches and their beak adaptations
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Convergent and Divergent Evolution
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Convergent Evolution:
- Unrelated organisms evolve similar traits due to similar selective pressures
- Example: Wings of bats and birds for flying
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Divergent Evolution:
- Related species evolve different traits due to different selective pressures
- Leads to the formation of new species
- Example: Ancestral mammals diversifying into various groups
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Coevolution
- Two or more species evolve in response to each other’s selective pressures
- Mutualistic, parasitic, or predator-prey relationships
- Example: Plants and pollinators, predator and prey adaptations
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Hardy-Weinberg Law
- Explains the genetic equilibrium in populations
- If certain conditions are met, allele and genotype frequencies remain constant over generations
- The equation: p² + 2pq + q² = 1
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Genetic Disorders
- Genetic disorders can be inherited or caused by mutations
- Examples: Cystic fibrosis, sickle cell anemia, Down syndrome
- Genetic counseling and testing can help in managing these disorders
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Evolutionary Biology Techniques
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Comparative genomics:
- Analyzing genomes of different organisms to understand their evolutionary relationships
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Phylogenetic trees:
- Diagrams that depict the evolutionary relationships between different species
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Molecular clock:
- Estimating the time of divergence between different species based on genetic mutations
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Paleontology:
- Studying fossils to understand the evolution of life on Earth
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Human Evolution
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Hominid evolution:
- The evolutionary history of humans and their ancestors
- Includes species like Australopithecines, Homo habilis, Homo erectus, Neanderthals, and Homo sapiens
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Out-of-Africa theory:
- Suggests that modern humans originated in Africa and migrated to other parts of the world
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Applications of Evolutionary Biology
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Agriculture:
- Breeding crops and livestock for desired traits
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Medicine:
- Understanding the genetic basis of diseases and developing treatments
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Conservation:
- Preserving biodiversity and managing endangered species
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Forensics:
- Using DNA analysis to solve criminal cases
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