Notes from NEET topper

Differences Between Positive and Negative Supercoiling

Positive Supercoiling: In positive supercoiling, the DNA is overwound or twisted in the same direction as its natural helical structure. It results in increased tension in the DNA molecule.

Negative Supercoiling: Negative supercoiling involves the DNA being underwound or twisted in the opposite direction of its natural helix. It results in reduced tension in the DNA molecule.

Both types of supercoiling can affect gene expression and DNA packaging.