Principles of Inheritance and Variation Question 198
198. The most striking example of point mutation is found in a disease called
[1995]
(a) thalassemia
(b) night blindness
(c) down’s syndrome
(d) sickle cell anaemia
Show Answer
Answer : d
Hints & Solution
(d) Sickle cell anaemia (in which nucleotide triplet GAG is changed to GUG) affects the $\beta$-globin chain of haemoglobin. Since these changes occur at a particular locus or point of a chromosome where specific gene is located, they are called as point mutation.
