Principles of Inheritance and Variation Question 169
169. G-6-P dehydrogenase deficiency is associated with haemolysis of:
[2005]
(a) leucocytes
(b) lymphocytes
(c) platelets
(d) $RBCs$
Show Answer
Answer : d
Hints & Solution
(d) Glucose-6-P dehydrogenase is the first enzyme of glucose oxidation during Pentose Phosphate Pathway. RBC contain haemoglobin which combines with oxygen to form oxyhaemoglobin which gives its oxygen for oxidation of food. In haemolysis, there is destruction of RBCs with release of haemoglobin into plasma resulting in jaundice. So, now RBCs cannot provide oxygen for oxidation of food thereby causing deficiency of G-6-P dehydrogenase.
