Neural Control and Coordination Question 55

55. Alzheimer disease in humans is associated with the deficiency of:

[2009]

(a) glutamic acid

(b) acetylcholine

(c) gamma aminobutyric acid (GABA)

(d) dopamine

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Answer : b

Hints & Solutions

(b) Alzheimer disease in humans is associated with the deficiency of acetylcholine. Acetylcholine is the neurotransmitter produced by neurons referred to as cholinergic neurons. Acetylcholine plays a role in skeletal muscle movement, as well as in the regulation of smooth muscle and cardiac muscle. Acetylcholine is synthesised from choline and acetyl coenzyme-A through the action of the enzyme choline acetyltransferase and becomes packaged into membrane-bound vesicles.